Music and painkillers combine?
Researchers have now found out that music to relieve pain and inflammation and the effect of pain can improve agents such as Ibuprofen and CBD.
In a recent study by the University of Utah, it was found that music helps to relieve pain and, in addition, the effect of certain painkillers. The results of the study were published in the English scientific journal “Frontiers in Neurology” published.
Combined effect of drugs and music studied
In recent years, the researchers played in their work in mice in the laboratory, the music of Mozart. So you want to find out more about the treatment of epilepsy and chronic pain. Pain and epilepsy are different symptoms, but similar problems. There are limited treatment options and available drugs are often not effective enough. In their development of new drugs against pain and epilepsy, the researchers investigated, such as drugs and music work together.
Music of Mozart weakens epilepsy
In various studies it has been shown that music by Mozart reduces the negative impact of epilepsy. In the current study, not only the effects of music on the disorder itself, but also on chronic pain were examined symptoms using mice and rats. The animals were playing the same Mozart compositions, which were also used previously in the experiments, the attenuation of epilepsy.
Pain relief was improved to more than 90 percent
The mice were exposed to three weeks prior to their participation in the treatment of the music. One group listened to music, the control group experienced only the normal ambient noise. The mice received one of four painkillers, including Ibuprofen, Levetiracetam, Cannabidiol (CBD) and the Galanin analog NAX 5055. The mice were then added to specific injuries, in order to simulate post-operative pain, and in some cases, a Virus was induced, which meant that the animals had seizures, the epilepsy impersonated. The pain relief by Ibuprofen, and music improved the results by more than 90 percent. The other models showed that the inflammation was reduced by 70 percent.
The music alone had only a small effect
The results showed that the music therapy had only a small effect. In combination with various drugs, the positive effects on the treatment of pain and inflammation. In addition, were not apparently needed a lot of painkillers in the System of the mice, in order to achieve the positive results. It was selected a dose of Ibuprofen, which has a relatively small effect. In the case of animals, which had previously come in contact with music, however, a strong improvement was observed.
Further research on humans is needed
The results not only showed a significant decrease in the seizures in the epileptic animals, but also a reduced number of disease-related deaths. It was found in the epilepsy model, an effect on the frequency of seizures, the most remarkable, however, was that actually a lower mortality rate could be observed, say the researchers. The model used for epilepsy-seizures showed normally, a mortality rate of up to 50 per cent., but by the combined treatment, this decreased significantly. Further research should find out whether a combination of music and painkillers have actually lowered the mortality rate in epilepsy and, in addition, the number of seizures can be better controlled. This could help to prevent a sudden and unexpected death due to epilepsy. There are already plans for the studies to continue in a clinical environment on humans. The researchers mainly try to understand what components of the intensification of the music, this type of pain-relieving and medicinal effects you want to achieve. (as)