(HealthDay)—Factors associated with in-hospital mortality include older age, chronic cardiac disease, and chronic pulmonary disease in a cohort of hospitalized patients with COVID-19 in New York City, according to a study published online May 19 in The Lancet.
Matthew J. Cummings, M.D., from the Columbia University Irving Medical Center and NewYork-Presbyterian Hospital in New York City, and colleagues conducted a prospective observational cohort study involving 1,150 adult patients admitted to two hospitals in Northern Manhattan from March 2 to April 1, 2020, who were diagnosed with laboratory-confirmed COVID-19; of these, 22 percent (257 patients) were critically ill.
The researchers found that of the 257 critically ill patients (median age, 62 years; 67 percent men), 82 percent had at least one chronic illness, most commonly hypertension and diabetes (63 and 36 percent, respectively); 46 percent of patients had obesity. Thirty-nine percent of patients had died as of April 28, 2020, and 37 percent remained hospitalized. Most patients (79 percent) received invasive mechanical ventilation (median, 18 days); 66 and 31 percent of patients received vasopressors and renal replacement therapy, respectively. Independent associations with in-hospital mortality were seen for older age (adjusted hazard ratio [aHR], 1.31 per 10-year increase), chronic cardiac disease (aHR, 1.76), chronic pulmonary disease (aHR, 2.94), higher concentrations of interleukin-6 (aHR, 1.11 per-decile increase), and higher concentrations of D-dimer (aHR, 1.10 per-decile increase).
“While waiting for the availability of a COVID-19 vaccine, further studies are required to improve and personalize patient treatment,” write the authors of an accompanying editorial.
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